The shufflon of IncI1 plasmids is rearranged constantly during different growth conditions

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Distribution of shufflon among IncI plasmids.

A shufflon or clustered inversion is a novel type of DNA rearrangement originally discovered in the IncI1 plasmid R64 (T. Komano, A. Kubo, and T. Nisioka, Nucleic Acids Res. 15:1165-1172, 1987). In a 1.95-kilobase region of R64 DNA, four DNA segments inverted independently or in groups, resulting in a complex DNA rearrangement. We found similar types of shufflon in other IncI1 plasmids, includi...

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Complete Genome Sequences of IncI1 Plasmids Carrying Extended-Spectrum β-Lactamase Genes

Extended spectrum beta-lactamases (ESBLs) confer resistance to clinically relevant antibiotics. Often, the resistance genes are carried by conjugative plasmids which are responsible for dissemination. Five IncI1 plasmids carrying ESBLs from commensal and clinical Escherichia coli isolates were completely sequenced and annotated along with a non-ESBL carrying IncI1 plasmid.

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ژورنال

عنوان ژورنال: Plasmid

سال: 2019

ISSN: 0147-619X

DOI: 10.1016/j.plasmid.2019.03.003